POLYDEXTROSE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Video Polydextrose what is it

Schwab, U., Louheranta, A., Torronen, A., and Uusitupa, M. Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism. Eur J Clin Nutr 2006;60(9):1073-1080. View abstract.

Achour L, Flourie B, Briet F, et al. Gastrointestinal effects and energy value of polydextrose in healthy nonobese men. Am J Clin Nutr 1994;59(6):1362-1368. View abstract.

Auerbach MH, Craig SA, Howlett JF, Hayes KC. Caloric availability of polydextrose. Nutr Rev 2007;65(12 Pt 1):544-549. View abstract.

Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. View abstract.

Craig SAS, Holden JF, Troup JP, Auerbach MH, Frier HI. Polydextrose as soluble fiber: Physiological and analytical aspects. Cereal Foods World 1998;43(5):370-376.

Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. View abstract.

Food Additive Status List. Available at: https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm#abb.

Hengst C, Ptok S, Roessler A, Fechner A, Jahreis G. Effects of polydextrose supplementation on different faecal parameters in healthy volunteers. Int J Food Sci Nutr 2009;60 Suppl 5:96-105. View abstract.

Hyvonen L, Linna M, Tuorila H, Dijksterhuis G. Perception of melting and flavor release of ice cream containing different types and contents of fat. J Dairy Sci 2003;86(4):1130-1138. View abstract.

Jie Z, Bang-Yao L, Ming-Jie X, et al. Studies on the effects of polydextrose intake on physiologic functions in Chinese people. Am J Clin Nutr 2000;72(6):1503-1509. View abstract.

Kimura Y, Nagata Y, Bryant CW, Buddington RK. Nondigestible oligosaccharides do not increase accumulation of lipid soluble environmental contaminants by mice. J Nutr 2002;132(1):80-87. View abstract.

Kimura Y, Nagata Y, Buddington RK. Some dietary fibers increase elimination of orally administered polychlorinated biphenyls but not that of retinol in mice. J Nutr 2004;134(1):135-142. View abstract.

King NA, Craig SA, Pepper T, Blundell JE. Evaluation of the independent and combined effects of xylitol and polydextrose consumed as a snack on hunger and energy intake over 10 d. Br J Nutr 2005;93(6):911-915. View abstract.

Kumemura M, Shimizu S, Tanizaki M, et al. The early phase of colon tumorigenesis induced by dimethylhydrazine in ICR mice. Oncol Rep 1998;5(3):621-624. View abstract.

Makivuokko H, Nurmi J, Nurminen P, Stowell J, Rautonen N. In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression. Nutr Cancer 2005;52(1):94-104. View abstract.

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Mitchell HL. “The role of the bulking agent polydextrose in fat replacement.” Handbook of Fat Replacers. Ed. Roller S, Jones SA. Boca Raton, FL: CRC Press LLC, 1996.

Mudgil D, Barak S. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review. Int J Biol Macromol 2013;61:1-6. View abstract.

Nakamura N, Gaskins HR, Collier CT, et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol 2009;75(4):1121-1128. View abstract.

Newberne PM, Conner MW, Estes P. The influence of food additives and related materials on lower bowel structure and function. Toxicol Pathol 1988;16(2):184-197. View abstract.

Ogata S, Fujimoto K, Iwakiri R, et al. Effect of polydextrose on absorption of triglyceride and cholesterol in mesenteric lymph-fistula rats. Proc Soc Exp Biol Med 1997;215(1):53-58. View abstract.

Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258. View abstract.

Satoh H, Hara T, Murakawa D, Matsuura M, Takata K. Soluble dietary fiber protects against nonsteroidal anti-inflammatory drug-induced damage to the small intestine in cats. Dig Dis Sci 2010;55(5):1264-1271. View abstract.

Setser CS, Racette WL. Macromolecule replacers in food products. Crit Rev Food Sci Nutr 1992;32(3):275-297. View abstract.

Setsu E. Cariogenicity of polydextrose and refined polydextrose as a substrate. Nichidai Koko Kagaku 1989;15(1):1-11. View abstract.

Shimomura, Y., Maeda, K., Nagasaki, M., Matsuo, Y., Murakami, T., Bajotto, G., Sato, J., Seino, T., Kamiwaki, T., and Suzuki, M. Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar. Biosci Biotechnol Biochem 2005;69(10):1819-1823. View abstract.

Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. View abstract.

Willis, H. J., Eldridge, A. L., Beiseigel, J., Thomas, W., and Slavin, J. L. Greater satiety response with resistant starch and corn bran in human subjects. Nutr Res 2009;29(2):100-105. View abstract.

Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. View abstract.

Schwab, U., Louheranta, A., Torronen, A., and Uusitupa, M. Impact of sugar beet pectin and polydextrose on fasting and postprandial glycemia and fasting concentrations of serum total and lipoprotein lipids in middle-aged subjects with abnormal glucose metabolism. Eur J Clin Nutr 2006;60(9):1073-1080. View abstract.

Achour L, Flourie B, Briet F, et al. Gastrointestinal effects and energy value of polydextrose in healthy nonobese men. Am J Clin Nutr 1994;59(6):1362-1368. View abstract.

Auerbach MH, Craig SA, Howlett JF, Hayes KC. Caloric availability of polydextrose. Nutr Rev 2007;65(12 Pt 1):544-549. View abstract.

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Bahrudin MF, Abdul Rani R, Tamil AM, Mokhtar NM, Raja Ali RA. Effectiveness of Sterilized Symbiotic Drink Containing Lactobacillus helveticus Comparable to Probiotic Alone in Patients with Constipation-Predominant Irritable Bowel Syndrome. Dig Dis Sci 2020;65(2):541-549. View abstract.

Berding K, Long-Smith CM, Carbia C, et al. A specific dietary fibre supplementation improves cognitive performance-an exploratory randomised, placebo-controlled, crossover study. Psychopharmacology (Berl) 2021;238(1):149-163. View abstract.

Burdock GA, Flamm WG. A review of the studies of the safety of polydextrose in food. Food Chem Toxicol 1999;37(2-3):233-264. View abstract.

Craig SAS, Holden JF, Troup JP, Auerbach MH, Frier HI. Polydextrose as soluble fiber: Physiological and analytical aspects. Cereal Foods World 1998;43(5):370-376.

Duncan PI, Enters-Weijnen CF, Emami N, et al. Short-term daily intake of polydextrose fiber does not shorten intestinal transit time in constipated adults: A randomized controlled trial. Nutrients. 2018;10(7). pii: E920. View abstract.

EFSA Panel on Food Additives and Flavourings (FAF), Younes M, Aquilina G, et al. Re-evaluation of polydextrose (E 1200) as a food additive. EFSA J 2021;19(1):e06363. View abstract.

Flood MT, Auerbach MH, Craig SA. A review of the clinical toleration studies of polydextrose in food. Food Chem Toxicol 2004;42(9):1531-1542. View abstract.

Food Additive Status List. Available at: https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm091048.htm#abb.

Hengst C, Ptok S, Roessler A, Fechner A, Jahreis G. Effects of polydextrose supplementation on different faecal parameters in healthy volunteers. Int J Food Sci Nutr 2009;60 Suppl 5:96-105. View abstract.

Hu Q, Niu Y, Yang Y, et al. Polydextrose Alleviates Adipose Tissue Inflammation and Modulates the Gut Microbiota in High-Fat Diet-Fed Mice. Front Pharmacol 2022;12:795483. View abstract.

Hyvonen L, Linna M, Tuorila H, Dijksterhuis G. Perception of melting and flavor release of ice cream containing different types and contents of fat. J Dairy Sci 2003;86(4):1130-1138. View abstract.

Ibarra A, Astbury NM, Olli K, Alhoniemi E, Tiihonen K. Effects of polydextrose on different levels of energy intake. A systematic review and meta-analysis. Appetite. 2015;87:30-7. View abstract.

Ibarra A, Olli K, Pasman W, et al. Effects of polydextrose with breakfast or with a midmorning preload on food intake and other appetite-related parameters in healthy normal-weight and overweight females: An acute, randomized, double-blind, placebo-controlled, and crossover study. Appetite. 2017;110:15-24. View abstract.

Ibarra A, Pelipyagina T, Rueffer M, Evans M, Ouwehand AC. Efficacy of Polydextrose Supplementation on Colonic Transit Time, Bowel Movements, and Gastrointestinal Symptoms in Adults: A Double-Blind, Randomized, Placebo-Controlled Trial. Nutrients 2019;11(2):439. View abstract.

Jie Z, Bang-Yao L, Ming-Jie X, et al. Studies on the effects of polydextrose intake on physiologic functions in Chinese people. Am J Clin Nutr 2000;72(6):1503-1509. View abstract.

King NA, Craig SA, Pepper T, Blundell JE. Evaluation of the independent and combined effects of xylitol and polydextrose consumed as a snack on hunger and energy intake over 10 d. Br J Nutr 2005;93(6):911-915. View abstract.

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Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, Barcelos IK, Leal RF, Ayrizono Mde L, Fagundes JJ, Teixeira Lde B, Ouwehand AC, Coy CS. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014 24;13:75. View abstract.

Maragkoudaki X, Naylor M, Papacleovoulou G, et al. Supplementation with a prebiotic (polydextrose) in obese mouse pregnancy improves maternal glucose homeostasis and protects against offspring obesity. Int J Obes (Lond) 2020;44(12):2382-2393. View abstract.

Martinelli M, Hick E, Walz F, Drago SR. Effects of cereal bar containing polydextrose on subjective feelings of appetite and energy intake in overweight adults over 15 d. Int J Food Sci Nutr. 2018;69(7):892-899. View abstract.

Mudgil D, Barak S. Composition, properties and health benefits of indigestible carbohydrate polymers as dietary fiber: a review. Int J Biol Macromol 2013;61:1-6. View abstract.

Nakamura N, Gaskins HR, Collier CT, et al. Molecular ecological analysis of fecal bacterial populations from term infants fed formula supplemented with selected blends of prebiotics. Appl Environ Microbiol 2009;75(4):1121-1128. View abstract.

Ogata S, Fujimoto K, Iwakiri R, et al. Effect of polydextrose on absorption of triglyceride and cholesterol in mesenteric lymph-fistula rats. Proc Soc Exp Biol Med 1997;215(1):53-58. View abstract.

Olli K, Salli K, Alhoniemi E, et al. Postprandial effects of polydextrose on satiety hormone responses and subjective feelings of appetite in obese participants. Nutr J. 2015;14:2. View abstract.

Saku K, Yoshinaga K, Okura Y, et al. Effects of polydextrose on serum lipids, lipoproteins, and apolipoproteins in healthy subjects. Clin Ther 1991;13(2):254-258. View abstract.

Setser CS, Racette WL. Macromolecule replacers in food products. Crit Rev Food Sci Nutr 1992;32(3):275-297. View abstract.

Shimada M, Nagano N, Goto S, et al. Effect of polydextrose intake on constipation in Japanese dialysis patients: A triple-blind, randomized, controlled trial. J Nutr Sci Vitaminol (Tokyo). 2015;61(4):345-53. View abstract.

Shimomura, Y., Maeda, K., Nagasaki, M., Matsuo, Y., Murakami, T., Bajotto, G., Sato, J., Seino, T., Kamiwaki, T., and Suzuki, M. Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar. Biosci Biotechnol Biochem 2005;69(10):1819-1823. View abstract.

Tiihonen K, Rautonen N, Alhoniemi E, Ahotupa M, Stowell J, Vasankari T. Postprandial triglyceride response in normolipidemic, hyperlipidemic and obese subjects – the influence of polydextrose, a non-digestible carbohydrate. Nutr J. 2015;14:23. View abstract.

Tomlin J, Read NW. A comparative study of the effects on colon function caused by feeding ispaghula husk and polydextrose. Aliment Pharmacol Ther 1988;2(6):513-519. View abstract.

Toporovski MS, de Morais MB, Abuhab A, Crippa Júnior MA. Effect of Polydextrose/Fructooligosaccharide Mixture on Constipation Symptoms in Children Aged 4 to 8 Years. Nutrients 2021;13(5):1634. View abstract.

Willis, H. J., Eldridge, A. L., Beiseigel, J., Thomas, W., and Slavin, J. L. Greater satiety response with resistant starch and corn bran in human subjects. Nutr Res 2009;29(2):100-105. View abstract.

Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. View abstract.

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