PHOSPHATIDYLSERINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

amaducci, l. Phosphatidylserine in the treatment of Alzheimer’s disease: results of a multicenter study. psychofarmaco.bull. 1988;24(1):130-134. see summary.

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gindin, j., novikov, m., kedar, d., walter-ginzburg, a., naor, s., and levi, s. The effect of vegetable phosphatidylserine on age-associated memory impairment and mood in the functional elderly. geriatric education and research institute and department of geriatrics; kaplan hospital; Rehovot, Israel 1995;

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palmieri, g., palmieri, r., inzoli, mr lombardi g., sottini, c., tavolato, b., and giometto, b. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. clin trials j 1987;24:73-83.

pepper, j. phosphatidylserine. i am j health syst.pharm. 10-15-1999;56(20):2038, 2043-2038, 2044. See abstract.

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rosadini, g., sannita, w. g., nobili, f., and cenacchi, t. phosphatidylserine: quantitative eeg effects in healthy volunteers. neuropsychobiology 1990;24(1):42-48. see summary.

starks, m. a., starks, s. L., Kingsley, M., Purple, M., and Jager, R. the effects of phosphatidylserine on the endocrine response to moderate-intensity exercise. jint soc.sports nutr 2008;5:11. see summary.

Vakhapova, V., Cohen, T., Richter, Y., Herzog, Y. and Korczyn, A. d. Phosphatidylserine containing omega-3 fatty acids may improve memory ability in non-demented elderly with memory problems: a double-blind, placebo-controlled trial. dement.geriatr cogn disord 2010;29(5):467-474. see summary.

villardita, j. c., grioli, s., salmeri, g., nicoletti, f., and pennisi, g. Multicenter clinical trial of brain phosphatidylserine in elderly patients with intellectual impairment. clin trials j 1987;24:84-93.

amaducci l. Phosphatidylserine in the treatment of Alzheimer’s disease: results of a multicenter study. psychopharmacology bull 1988;24:130-4.

Benton D, Donohoe Rt, Sillance B, Nabb S. The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor. nutr neurosci 2001;4:169-78. see summary.

blokland a, honig w, brouns f, jolles j. Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of PS from bovine cortex with PS from egg and PS from soybean. nutrition 1999;15:778-83. see summary.

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thief t, petrie w, wells c, massari dc. Effects of phosphatidylserine in Alzheimer’s disease. psychopharmacology bull 1992;28:61-6. see summary.

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Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff M. Double-blind, randomized, controlled study of phosphatidylserine in senile patients with dementia. acta neurol scan 1986;73:136-40. see summary.

engel rr, satzger w, gunther w, et al. double-blind crossover study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. eur neuropsychopharmacol 1992;2:149-55. see summary.

fahey td, pearl mrs. Hormonal and perceptual effects of phosphatidylserine administration during two weeks of resistance exercise-induced overtraining. biological sport 1998;15:135-44.

fda. qualified health declaration: final decision letter – phosphatidylserine and cognitive dysfunction and dementia. May 2003. Available at: https://wayback.archive-it.org/7993/20171114183737/https://www.fda.gov/food/ingredientspackaginglabeling/labelingnutrition/ucm072999.htm. accessed March 18, 2020.

funfgeld ew, baggen m, nedwidek p, et al. double-blind study with phosphatidylserine (ps) in parkinsonian patients with senile dementia of the alzheimer type (sdat). prog clin biol res 1989;317:1235-46. see summary.

heiss wd, kessler j, mielke r, et al. Long-term effects of phosphatidylserine, pyritinol, and cognitive training in Alzheimer’s disease. neuropsychological, electroencephalographic and pet research. dementia 1994;5:88-98. see summary.

hirayama s, terasawa k, rabeler r, et al. The effect of phosphatidylserine administration on memory and symptoms of attention deficit hyperactivity disorder: a randomized, double-blind, placebo-controlled clinical trial. diet j hum nutr. 2014;27 Supplement 2:284-91. see summary.

child pm. attention deficit/hyperactivity disorder (adhd) in children: justification for its integrative management. alternative medicine rev 2000;5:402-28. see summary.

child pm. phosphatidylserine; membrane nutrient for memory. a clinical and mechanistic evaluation. alternative medicine rev 1996; 1:70-84.

kim hy, akbar m, lau a, et al. inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). role of phosphatidylserine in the antiapoptotic effect. j biol chem 2000;275:35215-23.. see abstract.

maggioni m, picotti gb, bondiolotti gp, et al. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. acta psychiatr scand 1990;81:265-70. see summary.

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mallat z, benamer h, hugl b, et al. Elevated levels of detached membrane microparticles with procoagulant potential in peripheral circulating blood of patients with acute coronary syndromes. circulation 2000;101:841-3.. see abstract.

monastra g, cross ah, bruni a, et al. phosphatidylserine, a putative tumor necrosis factor inhibitor, prevents autoimmune demyelination. neurology 1993;43:153-63.. see abstract.

monteleone p, beinat l, tanzillo c, et al. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. neuroendocrinology 1990;52:243-8.. see abstract.

monteleone p, maj m, beinat l, et al. Chronic phosphatidylserine administration blunting of stress-induced activation of the hypothalamic-pituitary-adrenal axis in healthy men. eur j clin pharmacol 1992;42:385-8.. see abstract.

palmieri g, palmieri r, inzoli mr, et al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. clin trials j 1987;24:73-83.

pepper j. phosphatidylserine. am j health-syst pharm 1999;56:2038,2043-4.

schreiber s, kampf-sherf o, gorfine m, et al. An open-label trial of plant-derived phosphatidylserine for the treatment of age-related cognitive decline. isr j psychiatry relat sci 2000;37:302-7. see summary.

vakhapova v, cohen t, richter y, herzog y, kam y, korczyn ad. Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in older people without dementia with memory problems: results of an open-label extension study. dementia geriatric cognitive disorder. 2014;38(1-2):39-45. see summary.

villardita c, grioli s, salmeri g, et al. Multicenter clinical trial of brain phosphatidylserine in elderly patients with intellectual impairment. clin trials j 1987;24:84-93.

wells aj, hoffman jr, gonzalez am, et al. phosphatidylserine and caffeine attenuate post-exercise mood disorders and perception of fatigue in humans. nutres 2013;33:464-72. see summary.

yamazaki m, inoue a, koh cs, et al. Phosphatidylserine suppresses theiler’s murine encephalomyelitis virus-induced demyelinating disease. j neuroimmunol 1997;75:113-22.. see abstract.

zanotti a, valzelli l, toffano g. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. psychopharmacology (berl) 1989;99:316-21.. see abstract.

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