BETA-HYDROXYBUTYRATE (BHB): Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Video Beta hydroxybutyrate what is it

achanta lb, rae cd. ß-hydroxybutyrate in the brain: one molecule, multiple mechanisms. neurochemistry 2017;42(1):35-49. see summary.

achanta lb, rae cd. ß-hydroxybutyrate in the brain: one molecule, multiple mechanisms. neurochemistry 2017;42(1):35-49. see summary.

beylot m, chassard d, chambrier c, et al. Metabolic effects of d-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation. critical care doctor. 1994;22(7):1091-8. see summary.

beylot m, chassard d, chambrier c, et al. Metabolic effects of d-beta-hydroxybutyrate infusion in septic patients: inhibition of lipolysis and glucose production but not leucine oxidation. critical care doctor. 1994;22(7):1091-8. see summary.

Clarke K, Tchabanenko K, Pawlosky R, et al. Kinetics, safety and tolerability of (r)-3-hydroxybutyl (r)-3-hydroxybutyrate in healthy adult subjects. regul toxicol pharmacol. 2012;63(3):401-8. see summary.

Clarke K, Tchabanenko K, Pawlosky R, et al. Kinetics, safety and tolerability of (r)-3-hydroxybutyl (r)-3-hydroxybutyrate in healthy adult subjects. regul toxicol pharmacol. 2012;63(3):401-8. see summary.

cox pj, kirk t, ashmore t, et al. nutritional ketosis alters fuel preference and thus endurance performance in athletes. cell metab 2016;24(2):256-68. see summary.

cox pj, kirk t, ashmore t, et al. nutritional ketosis alters fuel preference and thus endurance performance in athletes. cell metab 2016;24(2):256-68. see summary.

evans m, cogan ke, egan b. Ketone body metabolism during exercise and training: physiological basis for exogenous supplementation. j physiol. 2017;595(9):2857-2871. see summary.

evans m, cogan ke, egan b. Ketone body metabolism during exercise and training: physiological basis for exogenous supplementation. j physiol. 2017;595(9):2857-2871. see summary.

evans m, patchett e, nally r, kearns r, larney m, egan b. Effect of acute ingestion of β-hydroxybutyrate salts on response to graded exercise in trained cyclists. eur j sport sci. 2018;18(3):376-86. see summary.

evans m, patchett e, nally r, kearns r, larney m, egan b. Effect of acute ingestion of β-hydroxybutyrate salts on response to graded exercise in trained cyclists. eur j sport sci. 2018;18(3):376-86. see summary.

Gautschi M, Weisstanner C, Slotboom J, Nava E, Zürcher T, Nuoffer JM. Highly efficient ketone body treatment in leukodystrophy related to multiple acyl-coa dehydrogenase deficiency. pediatrician res. 2015;77(1-1):91-8. see summary.

Gautschi M, Weisstanner C, Slotboom J, Nava E, Zürcher T, Nuoffer JM. Highly efficient ketone body treatment in leukodystrophy related to multiple acyl-coa dehydrogenase deficiency. pediatrician res. 2015;77(1-1):91-8. see summary.

gross ce, sandor p, fischer d. Preliminary data on exogenous ketone bodies in migraine prevention. headache 2017; 37(1s) 52-171.

gross ce, sandor p, fischer d. Preliminary data on exogenous ketone bodies in migraine prevention. headache 2017; 37(1s) 52-171.

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hashim sa, vanitallie tb. ketone body therapy: from the ketogenic diet to oral ketone ester administration. j res lipids. 2014;55(9):1818-26. see summary.

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hashim sa, vanitallie tb. ketone body therapy: from the ketogenic diet to oral ketone ester administration. j res lipids. 2014;55(9):1818-26. see summary.

hiraide a, katayama m, sugimoto h, yoshioka t, sugimoto t. Effect of 3-hydroxybutyrate on posttraumatic metabolism in man. surgery. 1991;109(2):176-81. see summary.

hiraide a, katayama m, sugimoto h, yoshioka t, sugimoto t. Effect of 3-hydroxybutyrate on posttraumatic metabolism in man. surgery. 1991;109(2):176-81. see summary.

Da Holdsworth, PJ Cox, T Kirk, H Stradling, S G Impey, K Clarke. a ketone ester drink increases post-exercise muscle glycogen synthesis in humans. med sci sports exercise. 2017;49(9):1789-1795. see summary.

Da Holdsworth, PJ Cox, T Kirk, H Stradling, S G Impey, K Clarke. a ketone ester drink increases post-exercise muscle glycogen synthesis in humans. med sci sports exercise. 2017;49(9):1789-1795. see summary.

kawakita t, uchino m, fukagawa k, et al. Randomized, multicenter, double-blind study of the safety and efficacy of 1% d-3-hydroxybutyrate eye drops for dry eye disease. science rep 2016;6:20855. see summary.

kawakita t, uchino m, fukagawa k, et al. Randomized, multicenter, double-blind study of the safety and efficacy of 1% d-3-hydroxybutyrate eye drops for dry eye disease. science rep 2016;6:20855. see summary.

kemper mf, srivastava s, todd king m, clarke k, veech rl, pawlosky rj. a ß-hydroxybutyrate ester regulates cholesterol biosynthesis in rats and a cholesterol biomarker in humans. lipids 2015;50(12):1185-93. see summary.

kemper mf, srivastava s, todd king m, clarke k, veech rl, pawlosky rj. a ß-hydroxybutyrate ester regulates cholesterol biosynthesis in rats and a cholesterol biomarker in humans. lipids 2015;50(12):1185-93. see summary.

malhi ms, duerson f, salabei jk, okonoboh p. Starvation ketoacidosis induced by ketogenic diet and ketone supplement consumption. curaus. 2021;13(6):e15778. published on June 20, 2021. see summary.

malhi ms, duerson f, salabei jk, okonoboh p. Starvation ketoacidosis induced by ketogenic diet and ketone supplement consumption. curaus. 2021;13(6):e15778. published on June 20, 2021. see summary.

mcnally ma, hartman al. ketone bodies in epilepsy. j neurochemistry. 2012;121(1):28-35. see summary.

mcnally ma, hartman al. ketone bodies in epilepsy. j neurochemistry. 2012;121(1):28-35. see summary.

myette-côté É, caldwell hg, ainslie pn, clarke k, little jp. A ketone monoester drink reduces the glycemic response to an oral glucose challenge in people with obesity: a randomized trial. i am j clin nutr. 2019;110(6):1491-1501. see summary.

myette-côté É, caldwell hg, ainslie pn, clarke k, little jp. A ketone monoester drink reduces the glycemic response to an oral glucose challenge in people with obesity: a randomized trial. i am j clin nutr. 2019;110(6):1491-1501. see summary.

newman jc, verdin e. ß-hydroxybutyrate: a signaling metabolite. annual rev nutr. 2017;37:51-76. see summary.

newman jc, verdin e. ß-hydroxybutyrate: a signaling metabolite. annual rev nutr. 2017;37:51-76. see summary.

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newport mt, vanitallie tb, kashiwaya y, king mt, veech rl. A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s disease. Alzheimer’s dementia. 2015;11(1):99-103. see summary.

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newport mt, vanitallie tb, kashiwaya y, king mt, veech rl. A new way to produce hyperketonemia: use of ketone ester in a case of Alzheimer’s disease. Alzheimer’s dementia. 2015;11(1):99-103. see summary.

pawan gl, simple sj. Effect of 3-hydroxybutyrate in obese subjects on very low energy diets and during therapeutic starvation. lancet. 1983;1(8314-5):15-7. see summary.

pawan gl, simple sj. Effect of 3-hydroxybutyrate in obese subjects on very low energy diets and during therapeutic starvation. lancet. 1983;1(8314-5):15-7. see summary.

plecko b, stoeckler-ipsiroglu s, schober e, et al. Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. pediatrician res. 2002;52(2):301-6. see summary.

plecko b, stoeckler-ipsiroglu s, schober e, et al. Oral beta-hydroxybutyrate supplementation in two patients with hyperinsulinemic hypoglycemia: monitoring of beta-hydroxybutyrate levels in blood and cerebrospinal fluid, and in the brain by in vivo magnetic resonance spectroscopy. pediatrician res. 2002;52(2):301-6. see summary.

prins pj, koutnik ap, d’agostino dp, et al. Effects of an exogenous ketone supplement on 5K running performance. jhum kinet 2020;72:115-127. see summary.

prins pj, koutnik ap, d’agostino dp, et al. Effects of an exogenous ketone supplement on 5K running performance. jhum kinet 2020;72:115-127. see summary.

putananickal n, gross ec, orsini al, et al. Efficacy and safety of exogenous beta-hydroxybutyrate for the preventive treatment of episodic migraine: a single-center, double-blind, randomized, placebo-controlled, crossover trial. headache 2022;42(4-5):302-311. see summary.

putananickal n, gross ec, orsini al, et al. Efficacy and safety of exogenous beta-hydroxybutyrate for the preventive treatment of episodic migraine: a single-center, double-blind, randomized, placebo-controlled, crossover trial. headache 2022;42(4-5):302-311. see summary.

reger ma, henderson st, hale c, et al. Effects of beta-hydroxybutyrate on cognition in adults with memory problems. neurobiol aging. 2004;25(3):311-4. see summary.

reger ma, henderson st, hale c, et al. Effects of beta-hydroxybutyrate on cognition in adults with memory problems. neurobiol aging. 2004;25(3):311-4. see summary.

simeone ta, simeone ka, stafstrom ce, rho jm. Do ketone bodies mediate the anticonvulsant effects of the ketogenic diet? neuropharmacology. 2018;133:233-241. see summary.

simeone ta, simeone ka, stafstrom ce, rho jm. Do ketone bodies mediate the anticonvulsant effects of the ketogenic diet? neuropharmacology. 2018;133:233-241. see summary.

soto-mota a, norwitz ng, evans rd, clarke k. exogenous d-ß-hydroxybutyrate lowers blood glucose in part by decreasing the availability of l-alanine for gluconeogenesis. endocrinol diabetes metab 2022;5(1):e00300. see summary.

soto-mota a, norwitz ng, evans rd, clarke k. exogenous d-ß-hydroxybutyrate lowers blood glucose in part by decreasing the availability of l-alanine for gluconeogenesis. endocrinol diabetes metab 2022;5(1):e00300. see summary.

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stefan m, sharp m, gheith r, lowery r, wilson j. the effect of exogenous beta-hydroxybutyrate salt supplementation on safety and health metrics in adolescents. nutrients 2021;13(3):854. see summary.

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stefan m, sharp m, gheith r, lowery r, wilson j. the effect of exogenous beta-hydroxybutyrate salt supplementation on safety and health metrics in adolescents. nutrients 2021;13(3):854. see summary.

thomsen hh, rittig n, johannsen m, et al. Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during lps-induced inflammation in humans: anticatabolic impact of ketone bodies. i am j clin nutr. 2018;108(4):857-67. see summary.

thomsen hh, rittig n, johannsen m, et al. Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during lps-induced inflammation in humans: anticatabolic impact of ketone bodies. i am j clin nutr. 2018;108(4):857-67. see summary.

valayannopoulos v, bajolle f, arnoux jb, et al. Successful treatment of severe cardiomyopathy in type III glycogen storage disease with d,l-3-hydroxybutyrate, high protein and ketogenic diet. pediatrician res. 2011;70(6):638-41. see summary.

valayannopoulos v, bajolle f, arnoux jb, et al. Successful treatment of severe cardiomyopathy in type III glycogen storage disease with d,l-3-hydroxybutyrate, high protein and ketogenic diet. pediatrician res. 2011;70(6):638-41. see summary.

van hove jl, grünewald s, jaeken j, et al. d,l-3-hydroxybutyrate treatment of multiple acyl-coa dehydrogenase deficiency (madd). lancet. 2003;361(9367):1433-5. see summary.

van hove jl, grünewald s, jaeken j, et al. d,l-3-hydroxybutyrate treatment of multiple acyl-coa dehydrogenase deficiency (madd). lancet. 2003;361(9367):1433-5. see summary.

van rijt wj, heiner-fokkema mr, du marchie sarvaas gj, et al. Favorable outcome after physiological dose of sodium-d,l-3-hydroxybutyrate in severe madd. pediatrics. 2014;134(4):e1224-8. see summary.

van rijt wj, heiner-fokkema mr, du marchie sarvaas gj, et al. Favorable outcome after physiological dose of sodium-d,l-3-hydroxybutyrate in severe madd. pediatrics. 2014;134(4):e1224-8. see summary.

waldman hs, basham sa, price fg, et al. Exogenous ketone salts do not improve cognitive responses after a high-intensity exercise protocol in healthy college-age men. appl physiol nutr metab. 2018;43(7):711-7. see summary.

waldman hs, basham sa, price fg, et al. Exogenous ketone salts do not improve cognitive responses after a high-intensity exercise protocol in healthy college-age men. appl physiol nutr metab. 2018;43(7):711-7. see summary.

walsh jj, neudorf h, little jp. 14-day ketone supplementation lowers glucose and improves vascular function in obesity: a randomized crossover trial. jclin endocrinol metab 2021;106(4):e1738-e1754. see summary.

walsh jj, neudorf h, little jp. 14-day ketone supplementation lowers glucose and improves vascular function in obesity: a randomized crossover trial. jclin endocrinol metab 2021;106(4):e1738-e1754. see summary.

woods wg, pawan gl, semple sj, ralphs dn. Effect of intravenous 3-hydroxybutyrate on postoperative nitrogen balance. hum nutr clin nutr. 1983;37(5):391-4. see summary.

woods wg, pawan gl, semple sj, ralphs dn. Effect of intravenous 3-hydroxybutyrate on postoperative nitrogen balance. hum nutr clin nutr. 1983;37(5):391-4. see summary.

woolf ec, syed n, scheck ac. Tumor metabolism, the ketogenic diet, and ß-hydroxybutyrate: novel approaches for brain tumor adjuvant therapy. mole frontal neurosci. 2016;9:122. see summary.

woolf ec, syed n, scheck ac. Tumor metabolism, the ketogenic diet, and ß-hydroxybutyrate: novel approaches for brain tumor adjuvant therapy. mole frontal neurosci. 2016;9:122. see summary.

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