Amoxicillin oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking.
To find out how this drug might interact with something else you’re taking, talk with your doctor or pharmacist.
Examples of drugs that can cause interactions with amoxicillin are listed below.
Drugs that increase the risk of side effects from amoxicillin
Taking amoxicillin with certain medications raises your risk of side effects from amoxicillin. This is because the amount of amoxicillin in your body may be increased. Examples of these drugs include:
- Probenecid: Taking probenecid with amoxicillin could lead to increased blood levels of amoxicillin. A doctor may need to decrease the dose of amoxicillin in some patients.
- Allopurinol: If you use these drugs together, you may develop a rash.
Interactions that increase the risk of side effects from other drugs
Taking amoxicillin with certain medications raises your risk of side effects from these medications. Amoxicillin increases the amount of these drugs in your body.
Examples of these drugs include drugs to treat blood clots. These are called anticoagulants and include warfarin (Coumadin), apixaban (Eliquis), Heparin, and others.
If you use them with amoxicillin, you have a higher risk of bleeding. Your doctor may adjust your dose of amoxicillin as a result.
Interactions that can make your drugs less effective
When amoxicillin is less effective: When amoxicillin is used with certain drugs, it may not work as well. In vitro studies have shown potential interactions that can cause the amount of amoxicillin in your body may be decreased.
Because in vitro studies are only conducted in a lab and not on live subjects, it is not clear whether this can significantly impact you if you’re taking amoxicillin with these drugs.
Nevertheless, examples of these drugs include:
- Chloramphenicol
- If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
- Macrolides, such as erythromycin, clarithromycin, or azithromycin
- If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
- Sulfonamides, such as sulfamethoxazole
- If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
- Tetracyclines, such as tetracycline or doxycycline
- If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same.
When other drugs are less effective: When certain drugs are used with amoxicillin, they may not work as well. This is because the amount of these drugs in your body may be decreased. Examples of these drugs include:
- Oral contraceptives (birth control)
- If you need to take amoxicillin, you should consider using a barrier method of birth control while on amoxicillin. Or, your doctor may prescribe a different form of birth control for you.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare professional about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you’re taking.
